Modeling of seizure transitions with ion concentration dynamics
نویسندگان
چکیده
منابع مشابه
Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
We investigate the effects of adding periodic stimulation to a generic, conductance-based neuron model that includes ion concentration dynamics of sodium and potassium. Under conditions of high extracellular potassium, the model exhibits repeating, spontaneous, seizure-like bursting events associated with slow modulation of the ion concentrations local to the neuron. We show that for a range of...
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Electrophysiological recordings show intense neuronal firing during epileptic seizures leading to enhanced energy consumption. However, the relationship between oxygen metabolism and seizure patterns has not been well studied. Recent studies have developed fast and quantitative techniques to measure oxygen microdomain concentration during seizure events. In this article, we develop a biophysica...
متن کاملTITLE : Oxygen and Seizure Dynamics : II . Computational Modeling 2 ABBREVIATED TITLE : Oxygen and Seizure Dynamics : II . Modeling
19 Electrophysiological recordings show intense neuronal firing during epileptic seizures leading to enhanced 20 energy consumption. However, the relationship between oxygen metabolism and seizure patterns has not 21 been well studied. Recent studies have developed fast and quantitative techniques to measure oxygen 22 microdomain concentration during seizure events. In this paper, we develop a ...
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We investigate the coupled dynamics of the local hydrodynamics and global electric response of an electrodialysis system, which consists of an electrolyte solution adjacent to a charge selective membrane under electric forcing. Under a dc electric current, counterions transport through the charged membrane while the passage of co-ions is restricted, thereby developing ion concentration polariza...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2015
ISSN: 1471-2202
DOI: 10.1186/1471-2202-16-s1-p242